A 62-year-old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of biliary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper-responsive to aggregating agents and produced an increased amount of thromboxane B2. A platelet storage pool deficiency was also found.
Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease) / C. G. Vergani, A. C. Plancher, M. Zuin, M. Cattaneo, C. Tramaloni, S. Maccari, P. Roma, A. L. Catapano. - In: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0014-2972. - 14:1(1984 Feb), pp. 49-54. [10.1111/j.1365-2362.1984.tb00703.x]
Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease)
M. Zuin;M. Cattaneo;A.L. Catapano
1984
Abstract
A 62-year-old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of biliary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper-responsive to aggregating agents and produced an increased amount of thromboxane B2. A platelet storage pool deficiency was also found.Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.