A 62-year-old man with clinical and biochemical findings consistent with homozygous Tangier disease is presented. Widespread atherosclerosis was present. Bile lipid analysis showed a low molar percentage of cholesterol with a low saturation index. The data suggest that high density lipoprotein cholesterol may act as a preferential precursor of biliary cholesterol. Coagulation and platelet studies indicated that the patient's platelets were hyper-responsive to aggregating agents and produced an increased amount of thromboxane B2. A platelet storage pool deficiency was also found.
Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease) / C. G. Vergani, A. C. Plancher, M. Zuin, M. Cattaneo, C. Tramaloni, S. Maccari, P. Roma, A. L. Catapano. - In: EUROPEAN JOURNAL OF CLINICAL INVESTIGATION. - ISSN 0014-2972. - 14:1(1984 Feb), pp. 49-54.
|Titolo:||Bile lipid composition and haemostatic variables in a case of high density lipoprotein deficiency (Tangier disease)|
|Parole Chiave:||Tangier Disease; Cholesterol, HDL; Apolipoproteins; Blood Coagulation Disorders; Blood Platelet Disorders; Humans; Lipids; Thromboxane B2; Aged; Lipoproteins, HDL; Hypolipoproteinemias; Apolipoprotein A-I; Cholesterol; Serotonin; Bile Acids and Salts; Bile; Middle Aged; Male|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||feb-1984|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1365-2362.1984.tb00703.x|
|Appare nelle tipologie:||01 - Articolo su periodico|