Test of HIV-Specific T lymphocyte function that detects exposure to HIV antigens and possibly early HIV infection

Methods for the detection of a T cell response in a patient to an antigen from an exogenous source are described. The antigen may be from any non-self source, but the method is particularly advantageous for detection of exposure to agents which do not produce rapid antibody responses. The method is particularly advantageous in detecting exposure to HIV and to other agents where early detection of exposure is important. The method detects activation of T cells in the absence of an antibody response