Fibroblasts play a major role in the development of systemic sclerosis (SSc), and the occurrence of serum autoantibodies reacting with fibroblast plasma membrane antigens in SSc has been reported. This study was undertaken to investigate whether IgG from SSc sera that react with human fibroblasts modulates the fibroblasts' function.

Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis / C. Chizzolini, E. Raschi, R. Rezzonico, C. Testoni, R. Mallone, A. Gabrielli, A. Facchini, N. Del Papa, M. O. Borghi, J. M. Dayer, P. L. Meroni. - In: ARTHRITIS AND RHEUMATISM. - ISSN 0004-3591. - 46:6(2002 Jun), pp. 1602-1613.

Autoantibodies to fibroblasts induce a proadhesive and proinflammatory fibroblast phenotype in patients with systemic sclerosis

E. Raschi;M. O. Borghi;P. L. Meroni
2002-06

Abstract

Fibroblasts play a major role in the development of systemic sclerosis (SSc), and the occurrence of serum autoantibodies reacting with fibroblast plasma membrane antigens in SSc has been reported. This study was undertaken to investigate whether IgG from SSc sera that react with human fibroblasts modulates the fibroblasts' function.
Sialoglycoproteins; Intercellular Adhesion Molecule-1; Humans; Seroepidemiologic Studies; Gene Expression; Aged; Fibroblasts; RNA, Messenger; Phenotype; Interleukin-1; Autoantibodies; Cells, Cultured; Adult; Immunoglobulin G; Interleukin-6; Scleroderma, Systemic; Middle Aged; Flow Cytometry; Up-Regulation; Interleukin 1 Receptor Antagonist Protein; Antirheumatic Agents; Male; Female; Cell Adhesion
Settore MED/16 - Reumatologia
ARTHRITIS AND RHEUMATISM
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/199775
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