Fibroblast activation is a crucial event in the development of systemic sclerosis (SSc). Antifibroblast autoantibodies (AFAs), detectable in the sera of SSc patients, are able to induce a proinflammatory phenotype on cultured fibroblasts. This study was undertaken to investigate the mechanisms of the interaction between AFAs and living fibroblasts.
Antifibroblast antibodies from systemic sclerosis patients are internalized by fibroblasts via a caveolin-linked pathway / N. Ronda, R. Gatti, R. Giacosa, E. Raschi, C. Testoni, P. L. Meroni, C. Buzio, G. Orlandini. - In: ARTHRITIS AND RHEUMATISM. - ISSN 0004-3591. - 46:6(2002 Jun), pp. 1595-1601.
Antifibroblast antibodies from systemic sclerosis patients are internalized by fibroblasts via a caveolin-linked pathway
E. Raschi;P. L. Meroni;
2002
Abstract
Fibroblast activation is a crucial event in the development of systemic sclerosis (SSc). Antifibroblast autoantibodies (AFAs), detectable in the sera of SSc patients, are able to induce a proinflammatory phenotype on cultured fibroblasts. This study was undertaken to investigate the mechanisms of the interaction between AFAs and living fibroblasts.
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