The biological features of malignant gliomas include high cell proliferation, extensive local infiltration of tumor cells into normal brain, and marked neovascularization. alphavbeta3 integrin is highly expressed in malignant gliomas and plays a role in glioma growth. This article investigates the in vitro and in vivo effects of a synthetic alphavbeta3 integrin inhibitor called IS20I on human malignant gliomas.

IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo / L. Bello, V. Lucini, C. Giussani, G. Carrabba, M. Pluderi, F. Scaglione, G. Tomei, R. Villani, P.M. Black, A. Bikfalvi, R.S. Carroll. - In: NEUROSURGERY. - ISSN 0148-396X. - 52:1(2003 Jan), pp. 177-185.

IS20I, a specific alphavbeta3 integrin inhibitor, reduces glioma growth in vivo

L. Bello;V. Lucini;F. Scaglione;
2003

Abstract

The biological features of malignant gliomas include high cell proliferation, extensive local infiltration of tumor cells into normal brain, and marked neovascularization. alphavbeta3 integrin is highly expressed in malignant gliomas and plays a role in glioma growth. This article investigates the in vitro and in vivo effects of a synthetic alphavbeta3 integrin inhibitor called IS20I on human malignant gliomas.
Cell Movement ; Neoplasm Invasiveness ; Animals ; Integrin alphaVbeta3 ; Antineoplastic Agents ; Humans ; Mice ; Mice, Nude ; Endothelium, Vascular ; Cell Survival ; Neoplasm Transplantation ; Brain Neoplasms ; Tumor Cells, Cultured ; Peptides, Cyclic ; Neovascularization, Pathologic ; Glioma ; Oligopeptides ; Cell Adhesion ; Cell Division
Settore MED/27 - Neurochirurgia
http://journals.lww.com/neurosurgery/pages/default.aspx
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/199631
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