N 6-Isopentenyladenosine (iPA), a member of the cytokinin family of plant hormones, exerts remarkable inhibition on tumor cell proliferation and apoptosis in several tumor cell lines. In this study, we report that iPA is able to inhibit the proliferation and promotes apoptosis in HCT-15 human colon cancer cells in a dose-dependent manner with a concentration of 2.5 μM, which causes 50% inhibition of cell viability. The cell cycle analysis by flow cytometry showed that iPA-induced growth arrest could be associated to apoptosis. Moreover, suppression of clonogenic activity occurs after exposure to iPA at a concentration of 2.5 μM for HCT-15.

Antiproliferative activity of N 6-isopentenyladenosine on HCT-15 colon carcinoma cell line / M. Rajabi, J. Mehrzad, E. Gorincioi, E. Santaniello. - In: NUCLEIC ACID THERAPEUTICS. - ISSN 2159-3337. - 21:5(2011 Oct), pp. 355-358.

Antiproliferative activity of N 6-isopentenyladenosine on HCT-15 colon carcinoma cell line

M. Rajabi;E. Gorincioi;E. Santaniello
2011-10

Abstract

N 6-Isopentenyladenosine (iPA), a member of the cytokinin family of plant hormones, exerts remarkable inhibition on tumor cell proliferation and apoptosis in several tumor cell lines. In this study, we report that iPA is able to inhibit the proliferation and promotes apoptosis in HCT-15 human colon cancer cells in a dose-dependent manner with a concentration of 2.5 μM, which causes 50% inhibition of cell viability. The cell cycle analysis by flow cytometry showed that iPA-induced growth arrest could be associated to apoptosis. Moreover, suppression of clonogenic activity occurs after exposure to iPA at a concentration of 2.5 μM for HCT-15.
N6-ISOPENTENYLADENOSINE ; PROLIFERATION ; NUCLEOSIDES ; APOPTOSIS ; AGENT
Settore BIO/10 - Biochimica
NUCLEIC ACID THERAPEUTICS
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/199581
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