In five large-scale prospective studies the predictive value of hemostatic parameters indicating the occurrence of arterial thrombotic diseases has been estimated in healthy individuals. All the studies have consistently found a statistically significant association between hyperfibrinogenemia and arterial thrombotic diseases. In two studies, increased levels of factor VII were associated with an increased incidence of ischemic heart disease. The relationship between arterial occlusive diseases and plasma levels of fibrinogen or factor VII was closer than that for other well established risk factors such as plasma cholesterol. These data indicate the important pathogenetic role carried out by alterations of the clotting system in occlusive arterial diseases.
PREDICTIVE VALUE OF COAGULATION TESTS IN ARTERIAL THROMBOSIS / M. CATTANEO, P. MANNUCCI. - In: LA RICERCA IN CLINICA E IN LABORATORIO. - ISSN 0390-5748. - 18:1(1988), pp. 1-7.
|Titolo:||PREDICTIVE VALUE OF COAGULATION TESTS IN ARTERIAL THROMBOSIS|
CATTANEO, MARCO NATALE (Primo)
MANNUCCI, PIER MANNUCCIO (Ultimo)
|Parole Chiave:||Factor VII; Fibrinogen; Myocardial infarction; Predictive tests; Stroke|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||1988|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF02918813|
|Appare nelle tipologie:||01 - Articolo su periodico|