Immunization of naive mice with beta2-glycoprotein I (beta2GPI) leads to the generation of pathogenic anticardiolipin antibodies associated with clinical manifestations of the antiphospholipid syndrome (APS). The aim of this study was to determine whether immunization of naive mice with human beta2GPI, which shares homology with mouse beta2GPI molecules, breaks tolerance to murine beta2GPI and leads to the generation of anti-mouse beta2GPI.

Immunization of naive BALB/c mice with human beta2-glycoprotein I breaks tolerance to the murine molecule / A. Tincani, B. Gilburd, M. Abu-Shakra, M. Blank, F. Allegri, R. Ottaviani, M. Riboni, P. L. Meroni, G. Balestrieri, Y. Shoenfeld. - In: ARTHRITIS AND RHEUMATISM. - ISSN 0004-3591. - 46:5(2002 May), pp. 1399-1404. [10.1002/art.10304]

Immunization of naive BALB/c mice with human beta2-glycoprotein I breaks tolerance to the murine molecule

P.L. Meroni;
2002

Abstract

Immunization of naive mice with beta2-glycoprotein I (beta2GPI) leads to the generation of pathogenic anticardiolipin antibodies associated with clinical manifestations of the antiphospholipid syndrome (APS). The aim of this study was to determine whether immunization of naive mice with human beta2GPI, which shares homology with mouse beta2GPI molecules, breaks tolerance to murine beta2GPI and leads to the generation of anti-mouse beta2GPI.
Animals; Humans; Cardiolipins; Mice; Mice, Inbred BALB C; Immune Tolerance; Immunization; Autoantibodies; Immunoglobulin G; beta 2-Glycoprotein I; Glycoproteins; Species Specificity; Female
Settore MED/16 - Reumatologia
mag-2002
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/199225
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