Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.
Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14 / F. Nicoletti, R. Di Marco, P. Sacerdote, P. Meroni, K. Mangano, C. Edwards, A. Bartorelli, K. Bendtzen, A. Panerai. - In: ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. - ISSN 0066-4804. - 45:5(2001 May), pp. 1591-1594. [10.1128/AAC.45.5.1591-1594.2001]
Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14
P. Sacerdote;P. Meroni;A. Bartorelli;A. Panerai
2001
Abstract
Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.
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