BACKGROUND/AIMS: Antibodies against nuclear pore complexes (NPCs) have been detected in primary biliary cirrhosis (PBC), but their clinical relevance is still unsettled. METHODS: We tested sera from 171 consecutive PBC patients and 230 control subjects (149 with autoimmune or viral liver diseases, 28 with systemic lupus erythematosus, and 53 healthy) by immunoblotting for antibodies against purified human NPCs. RESULTS: Antibodies to NPCs were detected in 27% of the patients with PBC, were highly specific (97%), and were not associated with antimitochondrial antibodies. Their prevalence was higher in symptomatic patients (36 vs. 16%, P < 0.01) and was associated (P < 0.001) with more severe disease, as assessed by the presence of cirrhosis or its complications (13% prevalence in patients without cirrhosis, 31% in uncomplicated, and 54% in complicated cirrhosis), or by the application of the Mayo prognostic model (12% in the lowest, 21% in the median, 47% in the highest score tertile). Positive patients had higher levels of serum bilirubin (2.2 +/- 3.7 vs. 1.0 +/- 1.1 mg/dl, P < 0.01) and more marked inflammatory infiltrates on liver biopsy (P < 0.05). CONCLUSIONS: Autoantibodies to NPCs are more prevalent in PBC patients than in controls and are strongly associated with more active and severe disease
Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis / P. Invernizzi, M. Podda, P. M. Battezzati, A. Crosignani, M. Zuin, E. Hitchman, M. Maggioni, P. L. Meroni, E. Penner, J. Wesierska-Gadek. - In: JOURNAL OF HEPATOLOGY. - ISSN 0168-8278. - 34:3(2001 Mar), pp. 366-372.
|Titolo:||Autoantibodies against nuclear pore complexes are associated with more active and severe liver disease in primary biliary cirrhosis|
|Parole Chiave:||Severity of Illness Index; Liver Diseases; Reference Values; Humans; Prognosis; Nuclear Pore; Autoantibodies; Lupus Erythematosus, Systemic; Liver; Bilirubin; Middle Aged; Liver Cirrhosis, Biliary; Models, Theoretical|
|Settore Scientifico Disciplinare:||Settore MED/16 - Reumatologia|
|Data di pubblicazione:||mar-2001|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0168-8278(00)00040-4|
|Appare nelle tipologie:||01 - Articolo su periodico|