Objectives: In a group of patients with Huntington's disease and age-matched controls, we studied the cortical silent period (SP) elicited by single transcranial magnetic stimulation (TMS) pulses. Methods: We measured the area of the pre-stimulus electromyographic (EMG) activity, the area of the motor evoked potentials (MEPs) and the duration of the SP induced by stimuli delivered at an intensity of 150% of motor threshold with a round coil placed over the vertex. We determined the cortical SP by sampling only the 5 traces containing the shortest SPs and by collecting 10 consecutive unselected traces without selecting trials. Results: Patients and controls had normal EMG background areas, and MEP latencies and areas. Whereas data measured from selected trials gave a normal duration of the SP (patients, 154 +/- 58 ins, controls, 166 +/- 22 ms), data from unselected trials yielded a significantly longer SP duration in patients than in controls (356 +/- 251 vs. 159 +/- 44 ms) and also a lamer variance and range. Conclusions: We conclude that in Huntington's disease, an abnormal cortical SP is best sought by collecting unselected consecutive traces. We suggest that the prolonged SP in HD originates from a dysfunction of the mechanisms controlling the restart of voluntary movement after TMS. (C) 2001 Elsevier Science Ireland Ltd. All ri-hts reserved.

The prolonged cortical silent period in patients with Huntington's disease / N. Modugno, A. Curra, M. Giovannelli, A. Priori, F. Squitieri, S. Ruggieri, M. Manfredi, A. Berardelli. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1388-2457. - 112:8(2001), pp. 1470-1474.

The prolonged cortical silent period in patients with Huntington's disease

A. Priori;
2001

Abstract

Objectives: In a group of patients with Huntington's disease and age-matched controls, we studied the cortical silent period (SP) elicited by single transcranial magnetic stimulation (TMS) pulses. Methods: We measured the area of the pre-stimulus electromyographic (EMG) activity, the area of the motor evoked potentials (MEPs) and the duration of the SP induced by stimuli delivered at an intensity of 150% of motor threshold with a round coil placed over the vertex. We determined the cortical SP by sampling only the 5 traces containing the shortest SPs and by collecting 10 consecutive unselected traces without selecting trials. Results: Patients and controls had normal EMG background areas, and MEP latencies and areas. Whereas data measured from selected trials gave a normal duration of the SP (patients, 154 +/- 58 ins, controls, 166 +/- 22 ms), data from unselected trials yielded a significantly longer SP duration in patients than in controls (356 +/- 251 vs. 159 +/- 44 ms) and also a lamer variance and range. Conclusions: We conclude that in Huntington's disease, an abnormal cortical SP is best sought by collecting unselected consecutive traces. We suggest that the prolonged SP in HD originates from a dysfunction of the mechanisms controlling the restart of voluntary movement after TMS. (C) 2001 Elsevier Science Ireland Ltd. All ri-hts reserved.
Chorea; Huntington's disease; Silent period; Transcranial magnetic stimulation
Settore MED/26 - Neurologia
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/198922
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