Deep brain stimulation (DBS) of subthalamic nucleus (STN) is an effective treatment for advanced Parkinson's disease. It also provides an opportunity to record neural activity from the human basal ganglia. In this study, to investigate the involvement of the human STN in sensory functions, we recorded somatosensory evoked potentials (SEPs) elicited by contralateral median-nerve stimulation, from STN electrodes implanted for DBS in patients with Parkinson's disease. We suggest that the STN N18 component of SEPs in Parkinson's disease is a mainly local field potential elicited by muscle afferent input to the nucleus. (C) 2003 Movement Disorder Society.
|Titolo:||Subthalamic somatosensory evoked potentials in Parkinson's disease|
|Parole Chiave:||Deep brain stimulation (DBS); Evoked potentials; Parkinson's disease; Somatosensory processing; Subthalamic nucleus (STN)|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
|Data di pubblicazione:||2003|
|Digital Object Identifier (DOI):||10.1002/mds.10519|
|Appare nelle tipologie:||01 - Articolo su periodico|