The concept of 'lifestyle' includes different factors such as nutrition, behavior, stress, physical activity, working habits, smoking and alcohol consumption. Increasing evidence shows that environmental and lifestyle factors may influence epigenetic mechanisms, such as DNA methylation, histone acetylation and miRNA expression. It has been identified that several lifestyle factors such as diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants, psychological stress and working on night shifts might modify epigenetic patterns. Most of the studies conducted so far have been centered on DNA methylation, whereas only a few investigations have studied lifestyle factors in relation to histone modifications and miRNAs. This article reviews current evidence indicating that lifestyle factors might affect human health via epigenetic mechanisms.

Epigenetics and lifestyle / J.A. Alegría Torres, A. Baccarelli, V. Bollati. - In: EPIGENOMICS. - ISSN 1750-1911. - 3:3(2011 Jun), pp. 267-277. [10.2217/epi.11.22]

Epigenetics and lifestyle

A. Baccarelli
Secondo
;
V. Bollati
Ultimo
2011

Abstract

The concept of 'lifestyle' includes different factors such as nutrition, behavior, stress, physical activity, working habits, smoking and alcohol consumption. Increasing evidence shows that environmental and lifestyle factors may influence epigenetic mechanisms, such as DNA methylation, histone acetylation and miRNA expression. It has been identified that several lifestyle factors such as diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants, psychological stress and working on night shifts might modify epigenetic patterns. Most of the studies conducted so far have been centered on DNA methylation, whereas only a few investigations have studied lifestyle factors in relation to histone modifications and miRNAs. This article reviews current evidence indicating that lifestyle factors might affect human health via epigenetic mechanisms.
DNA methylation; environmental exposures; epigenetics; histone modifications; lifestyle
Settore MED/44 - Medicina del Lavoro
giu-2011
Article (author)
File in questo prodotto:
File Dimensione Formato  
nihms498542.pdf

accesso aperto

Tipologia: Post-print, accepted manuscript ecc. (versione accettata dall'editore)
Dimensione 833.46 kB
Formato Adobe PDF
833.46 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/198809
Citazioni
  • ???jsp.display-item.citation.pmc??? 196
  • Scopus 387
  • ???jsp.display-item.citation.isi??? 328
social impact