Iron overload due to increased intestinal iron absorption represents an important clinical problem in patients with non-transfusion-dependent thalassemia (NTDT), particularly as they advance in age. Current models for iron metabolism in patients with beta (β)-thalassemia intermedia (TI) suggest that suppression of serum hepcidin results in increased iron absorption and release of iron from the reticuloendothelial system, leading to depletion of macrophage iron, relatively low levels of serum ferritin, and liver iron loading. The clinical consequences of iron overload in patients with NTDT are multifactorial and include endocrinopathy, bone disease, thromboembolism, pulmonary hypertension, cerebrovascular and neuronal damage, liver fibrosis or cirrhosis, and increased risk of hepatocellular carcinoma. Although serum ferritin levels correlate with liver iron concentration (LIC), they underestimate iron load in these patients compared with transfusion-dependent patients with equivalent LIC. Therefore, direct measurement of LIC is recommended with chelation therapy as indicated
Iron overload in non-transfusion-dependent thalassemia : a clinical perspective / K.M. Musallam, M.D. Cappellini, J.C. Wood, A.T. Taher. - In: BLOOD REVIEWS. - ISSN 0268-960X. - 26:Suppl. 1(2012 Apr), pp. S16-S19.
Titolo: | Iron overload in non-transfusion-dependent thalassemia : a clinical perspective | |
Autori: | CAPPELLINI, MARIA DOMENICA (Secondo) | |
Parole Chiave: | Beta-thalassemia intermedia; Iron overload; Liver iron; Non-transfusion-dependent thalassemia; Thalassemia | |
Settore Scientifico Disciplinare: | Settore MED/09 - Medicina Interna | |
Progetto: | Regolazione del metabolismo del ferro nell'eritropoiesi talassemica | |
Data di pubblicazione: | apr-2012 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/S0268-960X(12)70006-1 | |
Appare nelle tipologie: | 01 - Articolo su periodico |
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