The mechanisms underlying non-progression in HIV-1 infection are not well understood; however, this state has been associated previously with strong HIV-1-specific CD8+ T cell responses and the preservation of proliferative CD4+ T cell responses to HIV-1 antigens. Using a combination of interferon-gamma (IFN-γ) ELISpot assays and tetramer staining, the HIV-1-specific CD8+ T cell populations were quantified and characterized in untreated long-term HIV-1-infected non-progressors and individuals with slowly progressive disease, both in relation to CD4+ T cell responses, and in comparison with responses to cytomegalovirus (CMV) antigens. High levels of CD8+ T cell responses specific for HIV-1 or CMV were observed, but neither their frequency nor their phenotype seemed to differ between the two patient groups. Moreover, while CMV-specific CD4+ T cell responses were preserved in these donors, IFN-γ release by HIV-1-specific CD4+ T cells was generally low. These data raise questions with regard to the role played by CD8+ T cells in the establishment and maintenance of long-term non-progression.
Comparison between HIV- and CMV-specific T cell responses in long-term HIV infected donors / L Papagno, V Appay, J Sutton, T Rostron, GM Gillespie, GS Ogg, A King, AT Makadzanhge, A Waters, C Balotta, A Vyakarnam, PJ Easterbrook, SL Rowland-Jones. - In: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. - ISSN 0009-9104. - 130:3(2002), pp. 509-517.
|Titolo:||Comparison between HIV- and CMV-specific T cell responses in long-term HIV infected donors|
|Parole Chiave:||Cytotoxic T lymphocytes; HIV-1; Long-term non-progressor; T cell help; T cell maturation|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
|Data di pubblicazione:||2002|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1046/j.1365-2249.2002.02005.x|
|Appare nelle tipologie:||01 - Articolo su periodico|