Background and objectives: In a previous article, we showed that the pharmacokinetic set of remifentanil used for target-controlled infusion (TCI) might be biased in obese patients because it incoporates flawed equations for the calculation of lean body mass (LBM), which is a covariate of several pharmacokinetic paramiter in this set. The objectives of this study were to determine the predictive performance of the original pharmacokinetic set, which incorporates the James equation for LBM calculation, and to determine the predictive performance of the pharmacokinetic set when a new method to calculate LBM was used (the Janmahasatian equations).
|Titolo:||Predictive performance of the 'Minto' remifentanil pharmacokinetic parameter set in morbidly obese patients ensuing from new method for calculating lean body mass|
|Settore Scientifico Disciplinare:||Settore MED/41 - Anestesiologia|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||10.2165/11317690-000000000-00000|
|Appare nelle tipologie:||01 - Articolo su periodico|