Human immunodeficiency virus type 1 (HIV-1) isolability, rate of replication, phenotype, plasma viremia, and specific intracellular transcripts were cross-sectionally analyzed in 61 HIV-1-seropositive individuals to evaluate the correlations between the virological and molecular correlates of protection and progression in different clinical subsets: recently infected subjects (RIs), long-term nonprogressors (LTNPs), late progressors (LPs), and typical progressors (Tps). Comparison of the major virological and molecular features of HIV-1 infection has defined distinct profiles for different subsets of patients, LTNPs or RIs, as well as LPs or TPs, exhibited similar titers of coculture p24 antigen; the differences between the former and the latter were statistically significant at all the time points tested (p = 0.0001; 0.0003 and 0.0001), Whereas LTNPs and RIs revealed comparable low levels of indexes of viral replication, LPs and Tps showed higher genome and mRNA copy numbers (p = 0.0004 and p = 0.0008, respectively), We demonstrated close biological and molecular similarities between RIs and LTNPs on the one hand, and LPs and Tps on the other, In LTNPs both viral biological properties and viral load are important determinants of the course of the disease.
Comparable biological and molecular determinants in HIV type 1-infected long-term nonprogressors and recently infected individuals / C. Balotta, P. Bagnarelli, C. Riva, A. Valenza, S. Antinori, M.C. Colombo, R. Sampaolesi, M.B. Violin, M.P. de Pasquale, M. Moroni, M. Clementi, M. Galli. - In: AIDS RESEARCH AND HUMAN RETROVIRUSES. - ISSN 0889-2229. - 13:4(1997 Mar), pp. 337-341.
|Titolo:||Comparable biological and molecular determinants in HIV type 1-infected long-term nonprogressors and recently infected individuals|
BALOTTA, CLAUDIA (Primo)
GALLI, MASSIMO (Ultimo)
|Parole Chiave:||HIV seropositivity ; HIV progression ; phenotype ; plasma viremia ; CD4 lymphocyte count|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||mar-1997|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1089/aid.1997.13.337|
|Appare nelle tipologie:||01 - Articolo su periodico|