Oxidized LDL exhibits cytotoxic activity towards endothelial cells, which is thought to be mediated by the products derived also from cholesterol oxidation, mainly involving the B-ring. By LC-PB-EI-MS and EI-MS/MS analysis, we have identified 3 beta-hydroxy-5 alpha-cholest-6-ene-5-hydroperoxide among the cholesterol oxidation products in LDL incubated with micromolar concentrations of copper ions.
|Titolo:||Identification of 3 beta-hydroxy-5 alpha-cholest-6-ene-5-hydroperoxide in human oxidized LDL|
|Parole Chiave:||5α-hydroperoxycholesterol; Mass spectrometry; Oxidized human LDL; Oxysterols|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||29-mar-1996|
|Digital Object Identifier (DOI):||10.1016/0009-3084(95)02519-7|
|Appare nelle tipologie:||01 - Articolo su periodico|