IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.

AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.

P-31-magnetic resonance spectroscopy (P-31-MRS) is a non-invasive tool to study high-energy phosphate (HEP) metabolism. We evaluate whether P-31-MRS can detect early changes in kidney HEP metabolism during a 6-month trial with Valsartan. Twenty consecutive stable and normotensive kidney-transplanted patients were enrolled. Nine of them received short-term low-dose Valsartan treatment (80 mg/day) for 6 months, while 11 controls received no medication. Kidney HEP metabolism was evaluated both at baseline and after treatment by P-31-MRS with a 1.5 T system (Gyroscan Intera Master 1.5 MR System; Philips Medical Systems, Best, The Netherlands). Valsartan-treated patients (n = 9) showed a significant increase in beta-ATP/Pi ratio, a marker of kidney HEP metabolism (baseline = 1.03 +/- 0.08 vs. 6 months = 1.26 +/- 0.07, p = 0.03). In contrast, the beta-ATP/Pi ratio in the control group (n = 11) did not change (baseline = 0.85 +/- 0.10 vs. 6 months = 0.89 +/- 0.08, ns). The improvement in the beta-ATP/Pi ratio was not associated with a reduction in arterial blood pressure or in urinary albumin excretion. Kidney-localized P-31-MRS can detect early changes in kidney HEP metabolism during a short-term low-dose Valsartan treatment in stable normotensive kidney-transplanted patients.

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