This invention relates to a "one pot" process for the preparation of isoserine derivatives in high diastereoselective way. The process according to the invention includes the steps of reacting a protected glycidic acid with imines to yield isoserines protected both at the -OH and at the -COOH groups, deprotection of the obtained intermediates to isoserines or isoserine 1-4C- alkyl esters. Pure threo derivatives as the main isomer are obtained.

A process for the preparation of isoserine derivatives / F. Gabriele, M. L. Gelmi, F. Gassa.

A process for the preparation of isoserine derivatives

M. L. Gelmi;F. Gassa
2011-10-26

Abstract

This invention relates to a "one pot" process for the preparation of isoserine derivatives in high diastereoselective way. The process according to the invention includes the steps of reacting a protected glycidic acid with imines to yield isoserines protected both at the -OH and at the -COOH groups, deprotection of the obtained intermediates to isoserines or isoserine 1-4C- alkyl esters. Pure threo derivatives as the main isomer are obtained.
INDENA s.p.a.
EP2380871
EP0160022
Settore CHIM/06 - Chimica Organica
A process for the preparation of isoserine derivatives / F. Gabriele, M. L. Gelmi, F. Gassa.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/197519
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