In this study we evaluated the in vitro activities of cefditoren--a broad-spectrum oral cephalosporin--and other comparator agents against 2,396 fresh isolates from community-acquired respiratory tract infections, collected from 6 clinical Italian microbiology laboratories. On penicillin-susceptible pneumococci and Streptococcus pyogenes, cefditoren demonstrated to be the most active antibiotic (MIC(90)values of 0.03 and 0.06 mg/L respectively), showing only a slight decrease in potency on penicillin-intermediate and resistant pneumococci (MIC(90)value 0.5 mg/L, 1.0 mg/L respectively). All the other comparators displayed MIC(90 )values of 4 - 8 mg/L for penicillins and of 4 to >64 mg/L for the oral cephalosporins. Cefditoren and levofloxacin were the most active against MSSA (MIC(90)0.5 mg/mL). Cefditoren displayed a uniformly potent inhibitory activity (MIC(90)of 0.03 mg/L) against all strains of Haemophilus influenzae, regardless of their ampicillin resistance (mediated or not by beta-lactamase production), while against Moraxella catarrhalis MIC(90)values were higher against beta-lactamase-positive (0.25 mg/L). Cefditoren was active also against Klebsiella pneumoniae and Escherichia coli : in this case its activity was comparable with that of levofloxacin. In conclusion, cefditoren, due to its potent activity, is a new effective therapeutic option for the treatment of respiratory tract infections.
Antibacterial activity of cefditoren against major community-acquired respiratory pathogens recently isolated in Italy / S. Stefani, M. L. Mezzatesta, G. Fadda, R. Mattina, G. Palù, F. Rossano, M. A. Tufano, G. C. Schito, G. Nicoletti. - In: JOURNAL OF CHEMOTHERAPY. - ISSN 1120-009X. - 20:5(2008 Oct), pp. 561-9-569.
|Titolo:||Antibacterial activity of cefditoren against major community-acquired respiratory pathogens recently isolated in Italy|
|Parole Chiave:||Antimicrobials; CARTI; Cefditoren; Gram-negative; Gram-positive; MIC|
|Settore Scientifico Disciplinare:||Settore MED/07 - Microbiologia e Microbiologia Clinica|
|Data di pubblicazione:||ott-2008|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1179/joc.2008.20.5.561|
|Appare nelle tipologie:||01 - Articolo su periodico|