Extensive molecular modelling studies, including conformational analysis and the comparison of molecular electrostatic potential distributions, were used to evaluate structural parameters of new antagonists containing acyclic replacements of the N=C-N imidazole region. The synthesis and the biological screening of a series of acyl biphenyltetrazole derivatives were planned and realized to gain an insight into the structure-activity relationships of this unusual class of Angiotensin II antagonists. Copyright (C) 1997 Elsevier Science Ltd.
Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units / M. Angiolini, L. Belvisi, D. Poma, A. Salimbeni, N. Sciammetta, C. Scolastico. - In: BIOORGANIC & MEDICINAL CHEMISTRY. - ISSN 0968-0896. - 6:11(1998), pp. 2013-2027.
Design and synthesis of nonpeptide angiotensin II receptor antagonists featuring acyclic imidazole-mimicking structural units
L. BelvisiSecondo
;C. ScolasticoUltimo
1998
Abstract
Extensive molecular modelling studies, including conformational analysis and the comparison of molecular electrostatic potential distributions, were used to evaluate structural parameters of new antagonists containing acyclic replacements of the N=C-N imidazole region. The synthesis and the biological screening of a series of acyl biphenyltetrazole derivatives were planned and realized to gain an insight into the structure-activity relationships of this unusual class of Angiotensin II antagonists. Copyright (C) 1997 Elsevier Science Ltd.Pubblicazioni consigliate
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