Activation of tyrosine kinase receptors in epithelial cells results in the rapid disassembly of E-cadherin-mediated cell-cell adhesions. New research has identified Hakai, an E3-ubiquitin-ligase related to Cbl that binds E-cadherin in a tyrosine phosphorylation-dependent manner. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai may control epithelial-mesenchymal transitions under physiological and pathological conditions.
E-cadherin and Hakai: signalling, remodeling or destruction? / S. Pece, J. S. Gutkind. - In: NATURE CELL BIOLOGY. - ISSN 1465-7392. - 4:4(2002 Apr), pp. E72-4-E74.
E-cadherin and Hakai: signalling, remodeling or destruction?
S. PecePrimo
;
2002
Abstract
Activation of tyrosine kinase receptors in epithelial cells results in the rapid disassembly of E-cadherin-mediated cell-cell adhesions. New research has identified Hakai, an E3-ubiquitin-ligase related to Cbl that binds E-cadherin in a tyrosine phosphorylation-dependent manner. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai may control epithelial-mesenchymal transitions under physiological and pathological conditions.
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