Activation of tyrosine kinase receptors in epithelial cells results in the rapid disassembly of E-cadherin-mediated cell-cell adhesions. New research has identified Hakai, an E3-ubiquitin-ligase related to Cbl that binds E-cadherin in a tyrosine phosphorylation-dependent manner. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai may control epithelial-mesenchymal transitions under physiological and pathological conditions.

E-cadherin and Hakai: signalling, remodeling or destruction? / S. Pece, J. S. Gutkind. - In: NATURE CELL BIOLOGY. - ISSN 1465-7392. - 4:4(2002 Apr), pp. E72-4-E74.

E-cadherin and Hakai: signalling, remodeling or destruction?

S. Pece
Primo
;
2002-04

Abstract

Activation of tyrosine kinase receptors in epithelial cells results in the rapid disassembly of E-cadherin-mediated cell-cell adhesions. New research has identified Hakai, an E3-ubiquitin-ligase related to Cbl that binds E-cadherin in a tyrosine phosphorylation-dependent manner. By promoting the endocytosis and dynamic recycling or destruction of E-cadherin complexes, Hakai may control epithelial-mesenchymal transitions under physiological and pathological conditions.
Ubiquitin-Protein Ligases; Animals; Humans; beta Catenin; Tyrosine; Protein Binding; Cadherins; Endosomes; Models, Biological; Mesoderm; Saccharomyces cerevisiae; Down-Regulation; Epithelial Cells; Phosphorylation; Cytoskeletal Proteins; Trans-Activators; Signal Transduction; Cell Adhesion; Ligases
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/196829
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