Knowledge of the prevalence of congenital cytomegalovirus infection is necessary to evaluate the need for prevention. We performed a multicentre one-year study involving 11 neonatology divisions to ascertain the prevalence in Lombardy. Cytomegalovirus was isolated by culturing saliva samples from all babies born (n = 1268) of two 15-day sample periods and from 185 neonates with suspected congenital CMV based on clinical and laboratory findings and the history. The overall prevalence of congenital infection was 0.47% (6/1268) in the sample period group and 5% (9/185) in the second group. Clinical monitoring revealed sequelae in two of three children with symptomatic infection and no asymptomatic child at age two years. In a subgroup of 205 babies including 14 of the infected infants we also evaluated a test to detect cytomegalovirus DNA in the Guthrie cards obtained in neonatal screening for genetic and metabolic disorders. The test's sensitivity was 100% and specificity 98.5%, encouraging its use for early identification of infected neonates and for large epidemiological studies.
Congenital cytomegalovirus infection in a northern Italian region / M. Barbi, S. Binda, V. Primache, D. Clerici. - In: EUROPEAN JOURNAL OF EPIDEMIOLOGY. - ISSN 0393-2990. - 14:8(1998), pp. 791-796.
|Titolo:||Congenital cytomegalovirus infection in a northern Italian region|
BARBI, MARIA (Primo)
BINDA, SANDRO (Secondo)
PRIMACHE, VALERIA (Penultimo)
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||1998|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1023/A:1007554726449|
|Appare nelle tipologie:||01 - Articolo su periodico|