The pharmacokinetics of N-2-(p-chlorophenoxy)-isobutyryl-N'-morpholinomethylurea (plafibride, ITA 104) in rats, and its intestinal absorption, plasmatic biotransformation, urinary elimination and fecal excretion were previously studied. 1200 mg of plafibride orally were administered to 5 healthy volunteers and then the presence of the drug and its metabolites was studied in the serum. The presence of unchanged plafibride and clofibric acid was detected, whereas that of 2-(p-chlorophenoxy) isobutyrylurea was not. At the same time the platelet antiaggregating activity of plafibride was investigated in the 5 volunteers. In this study plafibride presented a good and long-lasting platelet antiaggregating activity.
Bioavailability of plafibride in healthy volunteers / E. Santaniello, F. Conti. J. Vilageliu, L. Bruseghini. - In: ARZNEIMITTEL-FORSCHUNG. - ISSN 0004-4172. - 31:10a(1981), pp. 1850-1852.
|Titolo:||Bioavailability of plafibride in healthy volunteers|
SANTANIELLO, ENZO (Primo)
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||1981|
|Appare nelle tipologie:||01 - Articolo su periodico|