The absorption spectrum of disulphonated Aluminum Phthalocyanine (AlS2Pc) was measured in vivo in a murine tumor model by time-resolved reflectance (TRR). Mice bearing the L1210 leukemia were administered intraperitoneally 2.5 mg/kg body weight of AlS2Pc. Reflectance measurements were performed in the 650-695 nm range before and 4 h after the drug administration. The absorption coefficient at each wavelength was obtained by fitting the experimental curve using the diffusion equation. The spectrum of the photosensitizer was obtained as a difference between the absorption of treated and untreated mice. The absorption spectrum of AlS2Pc was peaked at 685 nm, showing a red-shift of approximately 15 nm with respect to the spectrum in aqueous solution.

Absorption spectra of photosensitizers detected in vivo in tumor bearing mice / R. Cubeddu, G. Canti, A. Pifferi, P. Taroni, G. Valentini - In: Proceedings of SPIE / R. Cubeddu, R. Marchesini, S. R. Mordon , K. Svanberg, H. Rinneberg,et. - [s.l] : Society of Photo-Optical Instrumentation Engineers,Bellingham, WA, United States, 1995. - ISBN 0819416576. - pp. 237-242 [10.1117/12.198707]

Absorption spectra of photosensitizers detected in vivo in tumor bearing mice

G. Canti
Secondo
;
1995

Abstract

The absorption spectrum of disulphonated Aluminum Phthalocyanine (AlS2Pc) was measured in vivo in a murine tumor model by time-resolved reflectance (TRR). Mice bearing the L1210 leukemia were administered intraperitoneally 2.5 mg/kg body weight of AlS2Pc. Reflectance measurements were performed in the 650-695 nm range before and 4 h after the drug administration. The absorption coefficient at each wavelength was obtained by fitting the experimental curve using the diffusion equation. The spectrum of the photosensitizer was obtained as a difference between the absorption of treated and untreated mice. The absorption spectrum of AlS2Pc was peaked at 685 nm, showing a red-shift of approximately 15 nm with respect to the spectrum in aqueous solution.
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/196709
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