in primary breast cancers dichotomic classification of E-cadherin expression, according to an arbitrary cutoff, may be inadequate and lead to loss of prognostic significance or contrasting prognostic indications. We aimed to assess the prognostic value of high and low E-cadherin levels in a consecutive case series (204 cases) of unilateral node-negative non-lobular breast cancer patients with a 8-year median follow-up and that did not receive any adjuvant therapy after surgery.
An immunohistochemically positive E-cadherin status is not always predictive for a good prognosis in human breast cancer / P. Querzoli, D. Coradini, M. Pedriali, P. Boracchi, F. Ambrogi, E. Raimondi, R. La Sorda, R. Lattanzio, R. Rinaldi, M. Lunardi, C. Frasson, F. Modesti, S. Ferretti, M. Piantelli, S. Iacobelli, E. Biganzoli, I. Nenci, S. Alberti. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - 103:12(2010 Dec 07), pp. 1835-1839. [10.1038/sj.bjc.6605991]
An immunohistochemically positive E-cadherin status is not always predictive for a good prognosis in human breast cancer
P. Boracchi;F. Ambrogi;E. Biganzoli;
2010
Abstract
in primary breast cancers dichotomic classification of E-cadherin expression, according to an arbitrary cutoff, may be inadequate and lead to loss of prognostic significance or contrasting prognostic indications. We aimed to assess the prognostic value of high and low E-cadherin levels in a consecutive case series (204 cases) of unilateral node-negative non-lobular breast cancer patients with a 8-year median follow-up and that did not receive any adjuvant therapy after surgery.
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