The effects of compactin (ML-236 B) administration on bile saturation and on the activity of hepatic HMG-CoA reductase, acylCoA cholesterol acyl transferase and cholesterol 7α-hydroxylase were studied in hamsters fed either a standard or a lithogenic diet. In control animals, treatment with this compound resulted in a stimulation of HMG-CoA reductase associated with supersaturation of the bile. Hypercholesterolemic hamsters in which compactin reduced plasma cholesterol levels responded to the treatment with a decrease of both HMG-CoA reductase and cholesterol 7α-hydroxylase activities. Supersaturation of the bile induced by the lithogenic diet was not modified by compactin.
Effects of compactin (ML-236 B) on biliary lipid composition and cholesterol catabolism in the hamster / E. Bosisio, G. Cighetti, C. Di Padova, P. Rovagnati, M. Galli Kienle, G. Galli, R. Paoletti. - In: PHARMACOLOGICAL RESEARCH COMMUNICATIONS. - ISSN 0031-6989. - 14:7(1982 Jul), pp. 577-592.
Effects of compactin (ML-236 B) on biliary lipid composition and cholesterol catabolism in the hamster
E. BosisioPrimo
;G. CighettiSecondo
;G. GalliPenultimo
;R. PaolettiUltimo
1982
Abstract
The effects of compactin (ML-236 B) administration on bile saturation and on the activity of hepatic HMG-CoA reductase, acylCoA cholesterol acyl transferase and cholesterol 7α-hydroxylase were studied in hamsters fed either a standard or a lithogenic diet. In control animals, treatment with this compound resulted in a stimulation of HMG-CoA reductase associated with supersaturation of the bile. Hypercholesterolemic hamsters in which compactin reduced plasma cholesterol levels responded to the treatment with a decrease of both HMG-CoA reductase and cholesterol 7α-hydroxylase activities. Supersaturation of the bile induced by the lithogenic diet was not modified by compactin.Pubblicazioni consigliate
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