The identification of sterols and steroids formed by incubation of [7alph-3H, 26-14C]cholesterol with mitochondrial enzymes from bovine adrenal cortex is reported. Only 17% of the radioactivity associated with cholesterol metabolites was found in pregnenolone, whereas 15% was reliable to oxygenated sterols and 6% to steroid compounds. The significance of the formation of these compounds is discussed particularly as regards oxygenated cholesterol derivatives.
Catabolism of cholesterol by bovine adrenal-cortex enzymes: in vitro formation of oxygenated sterols and side-chain cleavage products / E. Bosisio, G. Galli, S. Nicosia, M. Galli Kienle. - In: EUROPEAN JOURNAL OF BIOCHEMISTRY. - ISSN 0014-2956. - 63:2(1976 Apr 01), pp. 491-497.
|Titolo:||Catabolism of cholesterol by bovine adrenal-cortex enzymes: in vitro formation of oxygenated sterols and side-chain cleavage products|
BOSISIO, ENRICA ANGELA (Primo)
GALLI, GIOVANNI CARLO (Secondo)
NICOSIA, SIMONETTA (Penultimo)
|Parole Chiave:||Animals; Cattle; Chromatography, Gas; Sterols; Adrenal Glands; Pregnenolone; Gas Chromatography-Mass Spectrometry; Mitochondria; Adrenal Cortex; Cholesterol|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
Settore BIO/10 - Biochimica
|Data di pubblicazione:||1-apr-1976|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1432-1033.1976.tb10252.x|
|Appare nelle tipologie:||01 - Articolo su periodico|