Tumor-associated chromosome translocations usually lead to the formation of two reciprocal fusion genes: one thought to be involved in the transformation process, the other the mechanical consequence of the translocation event. In the case of acute promyelocytic leukemia (APL) blasts, the 15;17 chromosome translocation generates the putatively transforming PML/RARa fusion gene and its reciprocal RARa/PML. We report APL cases with submicroscopic 15;17 recombinations leading to the formation of nonreciprocal PML/RARa or RARa/PML fusion genes. Therefore, each of the two reciprocal translocation products may be independently formed and selected by the leukemic phenotype, implying that both are involved in tumorigenesis.
|Titolo:||Acute promyelocytic leukemia cases with nonreciprocal PML/RARa or RARa/PML fusion genes|
|Parole Chiave:||Chromosomes, Human, Pair 17; Chromosomes, Human, Pair 15; Humans; In Situ Hybridization, Fluorescence; Translocation, Genetic; Tumor Suppressor Proteins; DNA, Neoplasm; Receptors, Retinoic Acid; Base Sequence; Neoplasm Proteins; Transcription Factors; Nuclear Proteins; Leukemia, Promyelocytic, Acute; Molecular Sequence Data; Oncogene Proteins, Fusion; Female; Male|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||1-mar-1995|
|Appare nelle tipologie:||01 - Articolo su periodico|