Two new gangliosides were isolated in pure form from beef brain. They were provisionally named ganglioside G5a and G5b. Ganglioside G5a is a monosialoganglioside containing fucose. Its basic neutral glycosphingolipid core is the gangliotetraose ceramide: Gal (1→3) GalNac (1→4) Gal (1→4) Glc (1→) ceramide, most likely with β linkages. Fucose is linked to the 2 position of external galactose, N acetylneuraminic acid to the 3 position of internal galactose. Ganglioside G5b is a mixture of at least two isomeric disialogangliosides containing N acetylneuraminic acid and N glycolylneuraminic acid. The major isomer has the following structure: NeuNac (α,2→3) Gal (β,1→3) GalNac (β,1→4)(NeuNglα,2→3) gal (β,1→4) Glc (β,1→) ceramide. The minor isomer contains N acetylneuraminic acid and N glycolylneuraminic acid in an inverted linkage position.
On the structure of two new gangliosides from beef brain / R. Ghidoni, S. Sonnino, G. Tettamanti, H. Wiegandt, V. Zambotti. - In: JOURNAL OF NEUROCHEMISTRY. - ISSN 0022-3042. - 27:2(1976 Aug), pp. 511-5-515.
On the structure of two new gangliosides from beef brain
R. GhidoniPrimo
;S. Sonnino;
1976
Abstract
Two new gangliosides were isolated in pure form from beef brain. They were provisionally named ganglioside G5a and G5b. Ganglioside G5a is a monosialoganglioside containing fucose. Its basic neutral glycosphingolipid core is the gangliotetraose ceramide: Gal (1→3) GalNac (1→4) Gal (1→4) Glc (1→) ceramide, most likely with β linkages. Fucose is linked to the 2 position of external galactose, N acetylneuraminic acid to the 3 position of internal galactose. Ganglioside G5b is a mixture of at least two isomeric disialogangliosides containing N acetylneuraminic acid and N glycolylneuraminic acid. The major isomer has the following structure: NeuNac (α,2→3) Gal (β,1→3) GalNac (β,1→4)(NeuNglα,2→3) gal (β,1→4) Glc (β,1→) ceramide. The minor isomer contains N acetylneuraminic acid and N glycolylneuraminic acid in an inverted linkage position.Pubblicazioni consigliate
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