Investigations on T cell receptor delta chain (TcR delta) gene expression in freshly isolated normal large granular lymphocytes, natural killer (NK) cell clones and NK bulk cultures revealed six T delta transcripts (3.5, 3.1, 2.2, 2.0, 1.5 and 1.3 kb) which varied in number and relative abundance in the different samples. None of the six known T delta variable regions was expressed and the T delta locus was retained in its germ-line configuration. The origin and significance of these NK-associated T delta transcripts are discussed.
|Titolo:||Natural killer cells carry the germ-line configuration of the T cell receptor delta chain gene and heterogeneously express six distinct delta transcripts|
PELICCI, PIER GIUSEPPE (Secondo)
|Parole Chiave:||Antigens, Differentiation, T-Lymphocyte; Gene Rearrangement, T-Lymphocyte; Antigens, CD3; Killer Cells, Natural; Humans; Gene Expression; Receptors, Antigen, T-Cell, gamma-delta; Receptors, Antigen, T-Cell; Transcription, Genetic|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||apr-1990|
|Digital Object Identifier (DOI):||10.1002/eji.1830200434|
|Appare nelle tipologie:||01 - Articolo su periodico|