Ig and T beta gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that approximately 10% of the cases tested displayed rearrangements of both Ig and T beta genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.
Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes / P. G. Pelicci, D. M. Knowles, R. Dalla Favera. - In: JOURNAL OF EXPERIMENTAL MEDICINE. - ISSN 0022-1007. - 162:3(1985 Sep 01), pp. 1015-24-1024.
Lymphoid tumors displaying rearrangements of both immunoglobulin and T cell receptor genes
P. G. PelicciPrimo
;
1985
Abstract
Ig and T beta gene rearrangements can be used as genetic markers of lineage and clonality in the study of B and T cell populations. We have addressed the issue of the respective B and T lineage specificity of these rearrangements by analyzing a panel of 63 lymphoid tumors representative of the various clinicopathologic categories of both B and T neoplasias. We report that approximately 10% of the cases tested displayed rearrangements of both Ig and T beta genes. Despite their dual genotypic pattern, these tumors retain a pure immunophenotype, i.e. they display either B or T cell lineage-restricted cell surface antigens. The implications of these findings for both normal and neoplastic lymphoid differentiation are discussed.Pubblicazioni consigliate
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