The antiproliferative activity of 2-(3,5-Dihydroxyphenyl)-6-hydroxybenzothiazole (DHB) is reported here. DHB inhibits the growth of human colon cancer HCT-15 with a 50% cell growth inhibition value of 23 μM and breast cancer MCF-7 with a 50% cell growth inhibition value of 41 μM in a dose/time dependent manner by using sulforhodamine B assay. Cell cycle analysis by flow cytometry showed that DHB-induced growth arrest could be associated with apoptosis in both cell lines. Moreover, suppression of clonogenic activity occurs after exposure to DHB at a concentration of 25 μM for HCT-15 and of 40 μM for MCF-7.
|Titolo:||Antiproliferative activity and cell cycle analysis of 2-(3,5-dihydroxyphenyl)-6-hydroxybenzothiazole on MCF-7 breast and HCT-15 colon cancer cell lines|
GHIDONI, RICCARDO (Ultimo)
|Parole Chiave:||antitumor; derivates; benzothiazole; resveratrol; discovery; potent; inhibitors; toxicity; analogs; agents|
|Settore Scientifico Disciplinare:||Settore BIO/10 - Biochimica|
|Data di pubblicazione:||ago-2011|
|Digital Object Identifier (DOI):||10.1089/dna.2011.1220|
|Appare nelle tipologie:||01 - Articolo su periodico|