In a randomized controlled trial of Interferon (IFN) in 60 patients (30 treated and 30 controls) with cryptogenic chronic active liver disease, 70% of treated patients showed complete response, but a high rate of biochemical relapse (62%) was noted. In these cases, a second response to higher doses of IFN has been more difficult and less frequent. A response to IFN was found in 88.5% of anti-HCV positive treated patients and only in 25% of anti-HCV negative. We suggest that serum anti-HCV is a suitable test to predict the response to IFN.
Interferon therapy of cryptogenic chronic active liver disease and its relationship to anti-HCV / G. Diodati, P. Bonetti, A. Tagger, A. Alberti, G. Realdi, A. Ruol. - In: ARCHIVES OF VIROLOGY. - ISSN 0304-8608. - 4:Suppl(1992), pp. 299-303.
Interferon therapy of cryptogenic chronic active liver disease and its relationship to anti-HCV
A. Tagger;
1992
Abstract
In a randomized controlled trial of Interferon (IFN) in 60 patients (30 treated and 30 controls) with cryptogenic chronic active liver disease, 70% of treated patients showed complete response, but a high rate of biochemical relapse (62%) was noted. In these cases, a second response to higher doses of IFN has been more difficult and less frequent. A response to IFN was found in 88.5% of anti-HCV positive treated patients and only in 25% of anti-HCV negative. We suggest that serum anti-HCV is a suitable test to predict the response to IFN.
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