The EH domain is an evolutionary conserved protein-protein interaction domain present in a growing number of proteins from yeast to mammals. Even though the domain was discovered just 5 years ago, a great deal has been learned regarding its three-dimensional structure and binding specificities. Moreover, a number of cellular ligands of the domain have been identified and demonstrated to define a complex network of protein-protein interactions in the eukaryotic cell. Interestingly, many of the EH-containing and EH-binding proteins display characteristics of endocytic "accessory" proteins, suggesting that the principal function of the EH network is to regulate various steps in endocytosis. In addition, recent evidence suggests that the EH network might work as an "integrator" of signals controlling cellular pathways as diverse as endocytosis, nucleocytosolic export, and ultimately cell proliferation.
|Titolo:||The EH network|
DI FIORE, PIER PAOLO (Ultimo)
|Parole Chiave:||Endocytosis; Phosphoproteins; Calcium-Binding Proteins; Biological Transport; Protein Structure, Tertiary; Protein Binding; Binding Sites|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||25-nov-1999|
|Digital Object Identifier (DOI):||10.1006/excr.1999.4694|
|Appare nelle tipologie:||01 - Articolo su periodico|