Doxorubicin and 4′-epidoxorubicin form chelate complexes with Cu(II), the structures of which are dependent on the drug-to-metal ratio r. The complex stoichiometry is defined by the structure of the drug, the pH and the r values. The cupric ion is able to evidence minor structural differences (doxorubicin versus 4′-epidoxorubicin), the substitution pattern of the antraquinone moiety and the self-association of the anthracycline ligand.

CHELATION OF COPPER(II) IONS BY DOXORUBICIN AND 4'-EPIDOXORUBICIN - ELECTRON-SPIN-RESONANCE EVIDENCE FOR A NEW COMPLEX AT HIGH ANTHRACYCLINE COPPER MOLAR RATIOS / V. MALATESTA, A. GERVASINI, F. MORAZZONI. - In: INORGANICA CHIMICA ACTA. - ISSN 0020-1693. - 136:2(1987), pp. 81-85.

CHELATION OF COPPER(II) IONS BY DOXORUBICIN AND 4'-EPIDOXORUBICIN - ELECTRON-SPIN-RESONANCE EVIDENCE FOR A NEW COMPLEX AT HIGH ANTHRACYCLINE COPPER MOLAR RATIOS

A. GERVASINI
Secondo
;
1987

Abstract

Doxorubicin and 4′-epidoxorubicin form chelate complexes with Cu(II), the structures of which are dependent on the drug-to-metal ratio r. The complex stoichiometry is defined by the structure of the drug, the pH and the r values. The cupric ion is able to evidence minor structural differences (doxorubicin versus 4′-epidoxorubicin), the substitution pattern of the antraquinone moiety and the self-association of the anthracycline ligand.
Settore CHIM/02 - Chimica Fisica
1987
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/195935
Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus 23
  • ???jsp.display-item.citation.isi??? 20
social impact