Doxorubicin and 4′-epidoxorubicin form chelate complexes with Cu(II), the structures of which are dependent on the drug-to-metal ratio r. The complex stoichiometry is defined by the structure of the drug, the pH and the r values. The cupric ion is able to evidence minor structural differences (doxorubicin versus 4′-epidoxorubicin), the substitution pattern of the antraquinone moiety and the self-association of the anthracycline ligand.
CHELATION OF COPPER(II) IONS BY DOXORUBICIN AND 4'-EPIDOXORUBICIN - ELECTRON-SPIN-RESONANCE EVIDENCE FOR A NEW COMPLEX AT HIGH ANTHRACYCLINE COPPER MOLAR RATIOS / V. MALATESTA, A. GERVASINI, F. MORAZZONI. - In: INORGANICA CHIMICA ACTA. - ISSN 0020-1693. - 136:2(1987), pp. 81-85.
CHELATION OF COPPER(II) IONS BY DOXORUBICIN AND 4'-EPIDOXORUBICIN - ELECTRON-SPIN-RESONANCE EVIDENCE FOR A NEW COMPLEX AT HIGH ANTHRACYCLINE COPPER MOLAR RATIOS
A. GERVASINISecondo
;
1987
Abstract
Doxorubicin and 4′-epidoxorubicin form chelate complexes with Cu(II), the structures of which are dependent on the drug-to-metal ratio r. The complex stoichiometry is defined by the structure of the drug, the pH and the r values. The cupric ion is able to evidence minor structural differences (doxorubicin versus 4′-epidoxorubicin), the substitution pattern of the antraquinone moiety and the self-association of the anthracycline ligand.Pubblicazioni consigliate
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