A rearrangement between the PML and RAR-alpha genes underlies the acute promyelocytic leukemia (APL)-specific t(15;17) translocation, leading to the production of a chimeric mRNA. Recent development of a reverse-transcription polymerase chain reaction (RT-PCR) assay for the PML/RAR-alpha hybrid has proven useful for rapid diagnosis and monitoring of minimal residual disease (MRD) in APL patients. Preliminary studies in which the prognostic significance of RT-PCR was evaluated indicate that this test may identify patients at high risk of relapse.
Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR / D. Diverio, P. P. Pandolfi, V. Rossi, A. Biondi, P. G. Pelicci, F. Lo Coco. - In: LEUKEMIA. - ISSN 0887-6924. - 8 Suppl 2:2(1994), pp. S63-5-S65.
Monitoring of treatment outcome in acute promyelocytic leukemia by RT-PCR
P. G. PelicciPenultimo
;
1994
Abstract
A rearrangement between the PML and RAR-alpha genes underlies the acute promyelocytic leukemia (APL)-specific t(15;17) translocation, leading to the production of a chimeric mRNA. Recent development of a reverse-transcription polymerase chain reaction (RT-PCR) assay for the PML/RAR-alpha hybrid has proven useful for rapid diagnosis and monitoring of minimal residual disease (MRD) in APL patients. Preliminary studies in which the prognostic significance of RT-PCR was evaluated indicate that this test may identify patients at high risk of relapse.
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