The endocrine effects of ovariectomy need to be further investigated. The present study was carried out to evaluate the influence of the adjuvant ovariectomy on the mastectomy-induced changes in PRL response to TRH in breast cancer. The study included 34 patients with locally limited breast carcinoma, 18 of whom were treated with radical mastectomy, whereas the other 16 underwent mastectomy plus adjuvant ovariectomy. PRL secretion in response to TRH (200 mcg I.V. as bolus) was evaluated one day before and 7 days after surgery. In patients treated with mastectomy only, PRL increase after TRH was significantly higher after surgery than before. On the contrary, no difference was seen in patients treated with mastectomy plus ovariectomy. This study shows that the adjuvant ovariectomy may block the increase in PRL response to TRH induced by mastectomy in breast cancer.
Effect of mastectomy versus mastectomy plus adjuvant ovariectomy on prolactin response to TRH in breast cancer / D. Ayala, P. Lissoni, C. Archili, S. Barni, G. Roveda, M. Giacomelli, A. Bissi. - In: JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS. - ISSN 0393-974X. - 4:4(1990 Oct), pp. 150-2-152.
|Titolo:||Effect of mastectomy versus mastectomy plus adjuvant ovariectomy on prolactin response to TRH in breast cancer|
GIACOMELLI, MAURIZIO PAOLO (Penultimo)
|Parole Chiave:||Prolactin; Humans; Adult; Breast Neoplasms; Aged; Ovariectomy; Middle Aged; Mastectomy; Female; Thyrotropin-Releasing Hormone|
|Settore Scientifico Disciplinare:||Settore MED/18 - Chirurgia Generale|
|Data di pubblicazione:||ott-1990|
|Appare nelle tipologie:||01 - Articolo su periodico|