We report the results of a study investigating signaling proteins in 26 cases of primary acute myelogenous leukemia. We studied the Shc adaptor proteins p52/p46Shc, which can activate the RAS/Mitogen Activated Protein kinase pathway, p66Shc which is uncoupled from RAS/MAP kinases and the MAP kinase family members Extracellular signal Regulated Kinase (ERK) and c-Jun NH2-terminal protein Kinase (JNK) or Stress Activated Protein Kinase (SAPK).
Expression and activation of SHC/MAP kinase pathway in primary acute myeloid leukemia blasts / P. Lunghi, A. Tabilio, S. Pinelli, G. Valmadre, E. Ridolo, R. Albertini, C. Carlo-Stella, P.P. Dall'Aglio, P.G. Pelicci, A. Bonati. - In: HEMATOLOGY JOURNAL. - ISSN 1466-4860. - 2:2(2001), pp. 70-80-80. [10.1038/sj/thj/6200095]
Expression and activation of SHC/MAP kinase pathway in primary acute myeloid leukemia blasts
C. Carlo-Stella;P.G. Pelicci;
2001
Abstract
We report the results of a study investigating signaling proteins in 26 cases of primary acute myelogenous leukemia. We studied the Shc adaptor proteins p52/p46Shc, which can activate the RAS/Mitogen Activated Protein kinase pathway, p66Shc which is uncoupled from RAS/MAP kinases and the MAP kinase family members Extracellular signal Regulated Kinase (ERK) and c-Jun NH2-terminal protein Kinase (JNK) or Stress Activated Protein Kinase (SAPK).
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