A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.
|Titolo:||The tripartite motif family identifies cell compartments|
|Parole Chiave:||Animals; Blotting, Northern; Carrier Proteins; Multigene Family; Humans; Two-Hybrid System Techniques; Subcellular Fractions; Organ Specificity; Mice; Protein Binding; Chromosome Mapping; Nerve Tissue Proteins; Cloning, Molecular; Mutagenesis, Site-Directed; In Situ Hybridization; Amino Acid Motifs; Cell Compartmentation; Molecular Sequence Data; Databases, Factual; Proteins; Sequence Homology, Amino Acid; Protein Structure, Tertiary; Embryo, Mammalian; Cell Line|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||1-mag-2001|
|Digital Object Identifier (DOI):||10.1093/emboj/20.9.2140|
|Appare nelle tipologie:||01 - Articolo su periodico|