We have investigated immunohistologically the cutaneous immune infiltrate in the lesions of five patients with severe, extensive lichen planus of recent onset before and after 15 days of oral, low-dose cyclosporine therapy (3 mg/kg/day). Before therapy, we observed an abnormal bandlike cellular infiltrate localized in the papillary dermis, composed mostly of CD3+ cells, with a prevalence of CD4+ cells. Infiltrating lymphocytes showed markers of activation (HLA-DR antigens and interleukin 2 receptor), and there were many Langerhans (CD1+) cells in the dermal infiltrate. After 15 days of cyclosporine therapy, we observed a dramatic decrease in the total number of T cells and a corresponding decrease in interleukin 2 receptor-positive activated CD25+ cells and in antigen-presenting cells (CD1+ and CD14b+). These changes were concurrent with clinical improvement. Our results are compatible with the hypothesis that the inhibition of CD4 T cells by cyclosporine might explain the drug's therapeutic action and that the interaction between antigen-presenting cells and CD4 T cells is important in the pathogenesis of lichen planus.
Immunohistologic evaluation of the effect of cyclosporine treatment on the lichen planus immune infiltrate / N. Mozzanica, A. Cattaneo, A. Legori, P. Pigatto, A. F. Finzi. - In: JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY. - ISSN 0190-9622. - 24:4(1991 Apr), pp. 550-4-554.
|Titolo:||Immunohistologic evaluation of the effect of cyclosporine treatment on the lichen planus immune infiltrate|
PIGATTO, PAOLO DANIELE MARIA (Penultimo)
|Parole Chiave:||Lichen Planus; Skin; Humans; Cyclosporins; Antibodies, Monoclonal; Langerhans Cells; HLA-DR Antigens; Antigens, CD; Adult; Middle Aged; Keratinocytes; Lymphocyte Subsets; Immunoenzyme Techniques; Male|
|Settore Scientifico Disciplinare:||Settore MED/35 - Malattie Cutanee e Veneree|
|Data di pubblicazione:||apr-1991|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/0190-9622(91)70080-L|
|Appare nelle tipologie:||01 - Articolo su periodico|