Alopecia is a common side effect of several anti-cancer drugs, including doxorubicin. Based on our recent observation that a monoclonal antibody (MAD11) directed against this anthracycline inhibits the systemic toxic effect of the drug in mice, we investigated the possibility that MAD11 administered topically might protect against doxorubicin-induced alopecia. In 31 of 45 young rats treated intraperitoneally with doxorubicin, alopecia was completely prevented by topical treatment of the skin with liposome-incorporated anti-doxorubicin monoclonal antibody. This type of treatment might find relevance in preventing anthracycline-induced alopecia in cancer patients. Our findings also provide the first demonstration that liposome-entrapped monoclonal antibodies are capable of penetrating the stratum corneum of the skin without losing their function.

Protection against doxorubicin-induced alopecia in rats by liposome-entrapped monoclonal antibodies / A. Balsari, D. Morelli, S. Ménard, U. Veronesi, M.I. Colnaghi. - In: THE FASEB JOURNAL. - ISSN 0892-6638. - 8:2(1994 Feb), pp. 226-230.

Protection against doxorubicin-induced alopecia in rats by liposome-entrapped monoclonal antibodies

A. Balsari
Primo
;
1994

Abstract

Alopecia is a common side effect of several anti-cancer drugs, including doxorubicin. Based on our recent observation that a monoclonal antibody (MAD11) directed against this anthracycline inhibits the systemic toxic effect of the drug in mice, we investigated the possibility that MAD11 administered topically might protect against doxorubicin-induced alopecia. In 31 of 45 young rats treated intraperitoneally with doxorubicin, alopecia was completely prevented by topical treatment of the skin with liposome-incorporated anti-doxorubicin monoclonal antibody. This type of treatment might find relevance in preventing anthracycline-induced alopecia in cancer patients. Our findings also provide the first demonstration that liposome-entrapped monoclonal antibodies are capable of penetrating the stratum corneum of the skin without losing their function.
Rats ; Antibodies, Monoclonal ; Animals ; Rats, Sprague-Dawley ; Skin ; Alopecia ; Liposomes ; Female ; Drug Carriers ; Doxorubicin
Settore MED/04 - Patologia Generale
feb-1994
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/194853
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