We measured mitogenic activity of whole blood serum and platelet-poor plasma-derived serum of a group of 10 patients with progressive systemic sclerosis and of 8 controls. Mitogenic activity of plasma-derived serum was greater in patients than in controls, in the absence of other signs of platelet activation. This increased activity was inhibited by specific antibodies, anti-platelet derived growth factor, suggesting that circulating levels of platelet-derived growth factor may be present in progressive systemic sclerosis patients. Platelet-derived growth factor, released either by platelets or by monocytes, might play a role in the pathogenesis of scleroderma.
|Titolo:||Increased plasma levels of platelet-derived growth factor activity in patients with progressive systemic sclerosis|
|Parole Chiave:||Platelet-Derived Growth Factor; Humans; DNA; Biological Assay; Scleroderma, Systemic; Cell Line; Immunoassay|
|Settore Scientifico Disciplinare:||Settore MED/35 - Malattie Cutanee e Veneree|
|Data di pubblicazione:||mag-1989|
|Digital Object Identifier (DOI):||10.3181/00379727-191-42880|
|Appare nelle tipologie:||01 - Articolo su periodico|