The synthesis of a series of 6-(4R-phenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones is reported. The compounds were evaluated for their oral antihypertensive activity in rats and some of them [(V b), R = NH2] and [(V c), R = NHCOCH3] were found to induce a high decrease in systolic blood pressure. Moreover all the compounds displayed an antithrombotic activity comparable to, or greater than, that of ASA.

Antihypertensive and antithrombotic activities of 6-(substitutedphenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones / D. Barlocco, A. Martini, G.A. Pinna, M.M. Curzu, F. Sala, M. Germini. - In: IL FARMACO. EDIZIONE SCIENTIFICA. - ISSN 0430-0920. - 42:8(1987), pp. 585-594.

Antihypertensive and antithrombotic activities of 6-(substitutedphenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones

D. Barlocco
Primo
;
1987

Abstract

The synthesis of a series of 6-(4R-phenyl)-5-hydroxymethyl-4,5-dihydro-3(2H)pyridazinones is reported. The compounds were evaluated for their oral antihypertensive activity in rats and some of them [(V b), R = NH2] and [(V c), R = NHCOCH3] were found to induce a high decrease in systolic blood pressure. Moreover all the compounds displayed an antithrombotic activity comparable to, or greater than, that of ASA.
Settore CHIM/08 - Chimica Farmaceutica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/194398
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