The fully diethoxyphosphoryl(Dep)-protected polyamines 1b-3b were prepared from the corresponding polyamines with 'diethyl phosphite' (= diethyl phosphonate) and CCl4 in a solid base/organic liquid two-phase system in the presence of Bu4NBr as phase-transfer catalyst. Subsequent phase-transfer-catalyzed alkylation of phosphoramidates 1b-3b with bis(chloromethyl)arenes 5-8 in the presence of Bu4N(HSO4) followed by deprotection gave good yields of polyazacyclophanes 9a-16a.
Diethoxyphosphoryl as a protecting-activating group in the synthesis of polyazacyclophanes / A. Chellini, R. Pagliarin, G. Giovenzana, G. Palmisano, M. Sisti. - In: HELVETICA CHIMICA ACTA. - ISSN 0018-019X. - 83:4(2000), pp. 793-800.
Titolo: | Diethoxyphosphoryl as a protecting-activating group in the synthesis of polyazacyclophanes |
Autori: | PAGLIARIN, ROBERTO (Secondo) |
Settore Scientifico Disciplinare: | Settore CHIM/06 - Chimica Organica |
Data di pubblicazione: | 2000 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1002/(SICI)1522-2675(20000412)83:4<793::AID-HLCA793>3.0.CO;2-3 |
Appare nelle tipologie: | 01 - Articolo su periodico |