Peripheral benzodiazepine receptors (PBR) modulate chemotaxis and cytokine production of monocytes and lymphocytes. Since PBR are decreased in animal models of stress and in patients with anxiety disorders, in the present study we analyze the ability of monocytes obtained from patients suffering from generalized anxiety to migrate towards chemoattracting benzodiazepines. In these patients, the benzodiazepine-induced chemotaxis is completely abolished, while the response to the control chemoattractant formyl-leu-met-phe is still maintained. The chemotaxis responses are not restored after pharmacological treatment of the pathology. The decreased chemotactic response could be linked to a decreased number of PBR receptors present on monocytes of generalized anxiety disorder patients.
Benzodiazepine-induced chemotaxis is impaired in monocytes from patients with generalized anxiety disorders / P.SACERDOTE, A.E.PANERAI, L.FRATTOLA, C.FERRARESE. - In: PSYCHONEUROENDOCRINOLOGY. - ISSN 0306-4530. - 24:2(1999), pp. 243-246.
|Titolo:||Benzodiazepine-induced chemotaxis is impaired in monocytes from patients with generalized anxiety disorders|
SACERDOTE, PAOLA GIUSEPPINA (Primo)
PANERAI, ALBERTO EMILIO (Secondo)
|Parole Chiave:||Anxiety disorder; Chemotaxis; Monocytes; Peripheral benzodiazepine receptor|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||1999|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/S0306-4530(98)00079-1|
|Appare nelle tipologie:||01 - Articolo su periodico|