Tumor Necrosis Factor-α (TNF-α) plays a pivotal role in psoriasis, an immuno-mediated and genetic skin disease. Anti-TNF-α inhibitors, such as etanercept, are widely used in clinical practice. By immunofluorescence, we investigated the expression of junctional transmembrane proteins in desmosomes (desmocollin-1, Dsc1; desmoglein-1, Dsg1), adherens junctions (E-cadherin), tight junctions (occludin), biomarkers of keratinocyte differentiation (keratin-10, K10; keratin-14, K14; keratin-16, K16; involucrin), epithelial proliferation and apoptosis in psoriatic skin before/after etanercept treatment (n = 5) and in control skin samples (n = 5). Occludin, K14, K16 and involucrin expressions were altered in psoriatic epidermis, while Dsc1, Dsg1, E-cadherin and K10 localisations were comparable to controls. Etanercept promoted the restoration of the physiological condition as suggested by a more differentiated keratinocyte phenotype and a reduced epidermal proliferation rate.
Etanercept restores a differentiated keratinocyte phenotype in psoriatic human skin: a morphological study / E. Donetti, A. Gualerzi, F. Ricceri, L. Pescitelli, M. Bedoni, F. Prignano. - In: EXPERIMENTAL DERMATOLOGY. - ISSN 0906-6705. - 21:7(2012), pp. 549-551.
|Titolo:||Etanercept restores a differentiated keratinocyte phenotype in psoriatic human skin: a morphological study|
DONETTI, ELENA BIANCA (Corresponding)
GUALERZI, ALICE (Secondo)
BEDONI, MARZIA (Penultimo)
|Settore Scientifico Disciplinare:||Settore BIO/16 - Anatomia Umana|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/j.1600-0625.2012.01518.x|
|Appare nelle tipologie:||01 - Articolo su periodico|