We examined 28 cases of primary bone lymphomas (PBL; stage IE) and 26 cases of systemic lymphomas involving the bone (SBL; stage IIE to IV). Two histologic types were prevalent: Diffuse large B-cell lymphomas (DLBCL; 26 PBL and 21 SBL) and CD30+ anaplastic large cell lymphomas (ALCL; 1 PBL and 4 SBL). A mature B phenotype (CD45+, CD20+, CD79a+, CDw75+/-, CD10-/+) was established in the DLBCL group. Bcl-2 immunoreactivity was demonstrated in 13/37 cases (35%), and bcl-6 immunostaining was observed in 22/32 cases (69%). ALCL showed null/T phenotype (CD3-/+; CD43+/-; CD30+), with ALK-1 expression in 3/3 cases. With use of a FR3A primer, a monoclonal pattern was demonstrated by PCR analysis in 22/41 lymphomas (54%). Bcl-2 translocation was identified in 2/41 cases (5%). This study details the clinical and pathological characteristics of bone lymphomas. Our immunohistochemical and molecular data suggest that most of them are "de novo" DLBCL and support their follicle center origin.
Lymphomas of the bone: a pathological and clinical study of 54 cases / U. Gianelli, C. Patriarca, A. Moro, M. Ponzoni, R. Giardini, M. Massimino, R. M. Alfano, E. Armiraglio, P. Nuciforo, S. Bosari, G. Coggi, A. Parafioriti. - In: INTERNATIONAL JOURNAL OF SURGICAL PATHOLOGY. - ISSN 1066-8969. - 10:4(2002 Oct), pp. 257-266.
|Titolo:||Lymphomas of the bone: a pathological and clinical study of 54 cases|
GIANELLI, UMBERTO (Primo)
COGGI, GUIDO (Penultimo)
|Parole Chiave:||Clone Cells; Animals; Lymphoma, Large B-Cell, Diffuse; Neoplasm Staging; Bone Neoplasms; Humans; Aged; Gene Rearrangement; Child; Age Distribution; DNA, Neoplasm; Polymerase Chain Reaction; Genes, bcl-2; Aged, 80 and over; Adult; Lymphoma, Large-Cell, Anaplastic; Middle Aged; Adolescent; Tumor Markers, Biological; Male; Immunoenzyme Techniques; Female; Proportional Hazards Models|
|Settore Scientifico Disciplinare:||Settore MED/08 - Anatomia Patologica|
|Data di pubblicazione:||ott-2002|
|Appare nelle tipologie:||01 - Articolo su periodico|