The study was carried out to determine the effect of a combination regimen of a small dose of calcitonin added to conjugated estrogens with medroxyprogesterone acetate on vertebral bone mass in early postmenopausal women. Comparisons were made with groups of women on calcitonin alone, on conjugated estrogens with medroxyprogesterone acetate alone, or on no treatment. The study was carried out over a 2-year period. The results of the study suggest that the combined regimen of calcitonin and estrogens increased vertebral bone mass in early postmenopausal women to a greater extent than calcitonin alone or estrogen alone. Increases in vertebral bone mass of 11.2% after 1 year and 9.2% after 2 years were demonstrated using the combined regimen. Both estrogens alone and calcitonin alone were, however, very effective in preventing rapid bone loss in the postmenopausal women studied.
A clinical trial on the effects of a combination of elcatonin (carbocalcitonin) and conjugated estrogens on vertebral bone mass in early postmenopausal women / M. Meschia, M. Brincat, P. Barbacini, P.G. Crossignani, W. Albisetti. - In: CALCIFIED TISSUE INTERNATIONAL. - ISSN 0171-967X. - 53:1(1993 Jul), pp. 17-20.
|Titolo:||A clinical trial on the effects of a combination of elcatonin (carbocalcitonin) and conjugated estrogens on vertebral bone mass in early postmenopausal women|
ALBISETTI, WALTER (Ultimo)
|Parole Chiave:||Estrogen Replacement Therapy ; Administration, Oral ; Calcitonin ; Analysis of Variance ; Drug Therapy, Combination ; Estrogens, Conjugated (USP) ; Spine ; Osteoporosis, Postmenopausal ; Bone Density ; Medroxyprogesterone ; Drug Synergism ; Biological Markers ; Female ; Menopause|
|Settore Scientifico Disciplinare:||Settore MED/33 - Malattie Apparato Locomotore|
Settore MED/34 - Medicina Fisica e Riabilitativa
Settore MED/40 - Ginecologia e Ostetricia
|Data di pubblicazione:||lug-1993|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/BF01352009|
|Appare nelle tipologie:||01 - Articolo su periodico|